Effects of Toona Sinensis Roem leaves ethanol extract on the perosixome proliferator-activated receptor of alpha/gamma expression in liver of high fat diet mice.
Tóm tắt: 19
| 
PDF: 15 
##plugins.themes.academic_pro.article.main##
Author
Từ khóa:
Toona sinensis
peroxisome proliferator-activated receptor
ethanol extracts
obese
liver
mice
Tóm tắt
Toona sinensis Roem leaves (TSL) has been used as a traditional medicine for obesity and diabetes. TSL ethanol extract (TSL-E) acted as a peroxisome proliferator-activated receptor of gamma (PPARg) ligand and revealed the hypoglycemic effect in high fat diet (HFD) fed mice. However, the effect of TSL-E on the steatohepatitis is not known. Levels of PPARa, PPARg, PCK2 and mHMGCs protein expression were investigated by using western blot. Results showed the expressions of PPARa and PPARg were significantly increased by TSL-E in liver, indicating that TSL-E is not only the PPARa ligand, but also the PPARg ligand. TSL-E was also found to activate the PPARa/g in HepG2 cells transiently transfected with the (PPRE)-tk-luciferase vector; compared with the PPARa/g specific full agonist, bezafibrate and PIO. In conclusion, TSL-E significantly elevates the expression of PPARa/g in liver of HFD mice.
Tài liệu tham khảo
-
[1] Caglayan, E., Blaschke, F., Takata, Y., & Hsueh, W. A. (2005), Metabolic syndrome-interdependence and metabolic pathways, Current Opinion in Pharmacology, 5(2), 135-142.
[2] Cai, E. P., & Lin, J. K. (2009), Epigallocatechin Gallate (EGCG) and Rutin Suppress the Glucotoxicity through Activating IRS2 and AMPK Signaling in Rat Pancreatic beta Cells, Journal of Agricultural and Food Chemistry, 57(20), 9817-9827.
[3] Carbone, V., Zhao, H. T., Chung, R., Endo, S., Hara, A., & El-Kabbani, O. (2009), Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase, Bioorganic & Medicinal Chemistry, 17(3), 1244-1250.
[4] Catov, J. M., Bodnar, L. M., Ness, R. B., Barron, S. J., & Roberts, J. M. (2007), Inflammation and dyslipidemia related to risk of spontaneous preterm birth, American Journal of Epidemiology, 166(11), 1312-1319.
[5] Chang, H. L., Hsu, H. K., Su, J. H., Wang, P. H., Chung, Y. F., Chia, Y. C., Tsai, L. Y., Wu, Y. C., & Yuan, S. S. F. (2006), The fractionated Toona sinensis leaf extract induces apoptosis of human ovarian cancer cells and inhibits tumor growth in a murine xenograft model, Gynecologic Oncology, 102(2), 309-314.
[6] Chao, C. Y., Mong, M. C., Chan, K. C., & Yin, M. C. (2010), Anti-glycative and anti-inflammatory effects of caffeic acid and ellagic acid in kidney of diabetic mice, Molecular Nutrition & Food Research, 54(3), 388-395.
[7] Chen, C. J., Michaelis, M., Hsu, H. K., Tsai, C. C., Yang, K. D., Wu, Y. C., Cinatl, J., & Doerr, H. W. (2008). Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication. Journal of Ethnopharmacology, 120(1), 108-111.
[8] Chen, H. M., Wu, Y. C., Chia, Y. C., Chang, F. R., Hsu, H. K., Hsieh, Y. C., Chen, C. C., & Yuan, S. S. (2009), Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anti-cancer activity in human prostate cancer cells, Cancer Letters, 286(2), 161-171.
[9] Chen, H. Y., Lin, Y. C., & Hsieh, C. L. (2007), Evaluation of antioxidant activity of aqueous extract of some selected nutraceutical herbs, Food Chemistry, 104(4), 1418-1424.
[10] Commerford, S. R., Ferniza, J. B., Bizeau, M. E., Thresher, J. S., Willis, W. T., & Pagliassotti, M. J. (2002), Diets enriched in sucrose or fat increase gluconeogenesis and G-6-Pase but not basal glucose production in rats, Am J Physiol Endocrinol Metab, 283(3), E545-555.
[11] Cong, W. N., Tao, R. Y., Tian, J. Y., Liu, G. T., & Ye, F. (2008), The establishment of a novel non-alcoholic steatohepatitis model accompanied with obesity and insulin resistance in mice, Life Sciences, 82(19-20), 983-990.
[12] Corl, B. A., Oliver, S. A. M., Lin, X., Oliver, W. T., Ma, Y., Harrell, R. J., & Odle, J. (2008), Conjugated linoleic acid reduces body fat accretion and lipogenic gene expression in, neonatal pigs fed low- or high-fat formulas, Journal of Nutrition, 138(3), 449-454.
[13] Crabb, D. W., Matsumoto, M., Chang, D., & You, M. (2004), Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology, Proceedings of the Nutrition Society, 63(01), 49-63.
[14] Cui, J., Xiao, Y., Shi, Y. H., Wang, B., & Le, G. W. (2012), Lipoic acid attenuates high-fat-diet-induced oxidative stress and B-cell-related immune depression, Nutrition, 28(3), 275-280.
[15] de Haan, J. B., Witting, P. K., Stefanovic, N., Pete, J., Daskalakis, M., Kola, I., Stocker, R., & Smolich, J. J. (2006), Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet, Journal of Lipid Research, 47(6), 1157-1167.
[16] Dunn, F. L., Higgins, L. S., Fredrickson, J., DePaoli, A. M., & Grp, I.-. (2011), Selective modulation of PPAR gamma activity can lower plasma glucose without typical thiazolidinedione side-effects in patients with Type 2 diabetes, Journal of Diabetes and Its Complications, 25(3), 151-158.
[17] Eaton, S., Bartlett, K., & Pourfarzam, M. (1996), Mammalian mitochondrial beta-oxidation, Biochemical Journal, 320, 345-357.
[18] Eisenste.Ab, Strack, I., & Steiner, A. (1973), Effects of a High Fat, Carbohydrate-Free Diet on Gluconeogenesis in Rat-Liver, American Journal of Clinical Nutrition, 26(7), R19-R19.
[19] Eisenste.Ab, Strack, I., & Steiner, A. (1974), Increased Hepatic Gluconeogenesis without a Rise of Glucagon-Secretion in Rats Fed a High Fat Diet, Diabetes, 23(11), 869-875.
Xem thêm
##plugins.themes.academic_pro.article.sidebar##
Đã Xuất bản
Jun 30, 2015
Download
Cách trích dẫn
Ta Ngoc Ly*; Chang Sue Joan. “Effects of Toona Sinensis Roem Leaves Ethanol Extract on the Perosixome Proliferator-Activated Receptor of alpha/Gamma Expression in Liver of High Fat Diet Mice”. Tạp Chí Khoa học Và Công nghệ - Đại học Đà Nẵng, vol 6, số p.h 91, Tháng Sáu 2015, tr 87-92, https://jst-ud.vn/jst-ud/article/view/1034.
