PTP1B INHIBITORY CONSTITUENTS IN VIETNAM MEDICINAL PLANT ORTHOSIPHON STAMINEUS BENTH..

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Author

  • Hoang Duc Thuan, Nguyen Phi Hung*, Nguyen Thi Thao, Vu Quoc Trung, Pham Quoc Long

Keywords:

Orthosiphon stamineus Benth
caffeic acid
ursolic acid
Cat’s whiskers
PTP1B inhibitors

Abstract

The methanolic extract of the aerial part of a Vietnam medicinal plant Orthosiphon stamineus Benth in Vietnam shows an inhibitory effect of over 65% inhibition on Protein Tyrosine Phosphatase 1B (PTP1B) enzyme at a concentration of 30 µg/mL. By using assay-guided isolation, four compounds including protocatechuic acid (1), p-hydroxybenzoic acid (2), caffeic acid (3) và methyl 3,4-dihydroxycinnamate (4) have been isolated and structurally identified through spectroscopic (NMR, IR, and MS) data analysis. All of the isolated compounds (1‒4) are tested for their inhibitory effects on PTP1B enzyme activity. As a result, all of these isolated exhibited inhibitory effects on PTP1B with IC50 have values of 29,59 ± 3,99, 24,75 ± 1,12, 27,05 ± 2,94, and 36,12 ± 0,89 µM, respectively. In this essay, ursolic acid shows an IC50 value of 4,12 ± 0,09 µM.

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Published

May 31, 2017
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How to Cite
Hoang Duc Thuan, Nguyen Phi Hung*, Nguyen Thi Thao, Vu Quoc Trung, Pham Quoc Long. “PTP1B INHIBITORY CONSTITUENTS IN VIETNAM MEDICINAL PLANT ORTHOSIPHON STAMINEUS BENTH.”. The University of Danang - Journal of Science and Technology, vol. 5, no. 114.1, May 2017, pp. 136-9, https://jst-ud.vn/jst-ud/article/view/3201.

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