Synthesis of 1,5-disubstituted 1,2,3-triazole via multi-component reaction

https://doi.org/10.31130/jst-ud2020-102E

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Author

  • Vo Viet Dai, Do Thi Phuong Thu, Nguyen Tran Nguyen

Từ khóa:

multi-component reaction
1,5-disubstituted 1,2,3-triazole
substituted 1,2,3-triazole

Tóm tắt

1,5-Disubstituted 1,2,3-triazoles are synthesized viametal-free multi-component reaction from primary amine, ketones and 4-nitrophenyl azide. The structure of three target compounds including:1-(4-methoxybenzyl)-5-(4-methylphenyl)-1H-1,2,3-triazole (1), 1-(4-methoxybenzyl)-5-(4-nitrophenyl)-1H-1,2,3-triazole (2) and 1-(4-methoxybenzyl)-5-phenyl-1H-1,2,3-triazole (3) is elucidated and identified by infrared spectroscopy, nuclear magnetic resonance spectroscopic analysis and high resolution mass spectrum. The formation of heterocyclic aromatic 1,2,3-triazole ring is approved by the appearance of singlet peak at 7.71 ppm in 1H NMR corresponding with triazolyl proton.
In addition, antibacterial and antifungal activities of products are also tested with three Gram-positive bacteria (B. subtilis, S. aureus and L. fermentum), three Gram-negative bacteria (P. aeruginosa, E.coli, S. enterica), and Candida albicans fungus.

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Jun 30, 2020
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Vo Viet Dai, Do Thi Phuong Thu, Nguyen Tran Nguyen. “Synthesis of 1,5-Disubstituted 1,2,3-Triazole via Multi-Component Reaction”. Tạp Chí Khoa học Và Công nghệ - Đại học Đà Nẵng, vol 18, số p.h 6, Tháng Sáu 2020, tr 77-81, doi:10.31130/jst-ud2020-102E.

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