α-glucosidase inhibitors from the leaves and stems of Erythrina Variegata L. collected in Hanoi

https://doi.org/10.31130/ud-jst.2023.040E
Tóm tắt: 176 | PDF: 127

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Author

  • Phi-Hung Nguyen
    Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), Vietnam
    Savanchith Xayavong
    Faculty of Chemistry, Hanoi National University of Education, Vietnam
    Ngoc-Thao-Vy Trinh
    University of Medicine and Pharmacy at Ho Chi Minh City (UMP HCM); Faculty of Medicine and Pharmacy, Tay Nguyen University, Vietnam
    Dang Ngoc Quang
    Faculty of Chemistry, Hanoi National University of Education, Vietnam
    Le Thi Phuong Hoa
    Faculty of Biology, Hanoi National University of Education, Vietnam
    Thi-Thuy Do
    Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), Vietnam
    Thi-Ha Vu
    Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), Vietnam
    Thi-Thuc Bui
    Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), Vietnam
    Thi-Thu-Ha Trinh
    Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), Vietnam

Từ khóa:

Erythrina variegata
α-glucosidase inhibitor
anti-diabetic
anti-obesity
Vong nem

Tóm tắt

Four secondary metabolites, including daidzein (1), genistein (2), glycitein (3), and daidzin (4) have been isolated and structural elucidated from the methanolic extract of the stems and leaves of Erythrina variegata L. collected in Hanoi city, Vietnam. These compounds showed good in vitro inhibition on α-glucosidase enzyme with IC50 values of 97.6 ± 0.6, 230.4 ± 0.4, 34.3 ± 0.9, and 217.2 ± 0.2 µM, respectively as compared with that of acarbose (IC50 value of 125.8 ±
1.2 µM). This finding suggests the possible application of product containing high content of these compounds from the leaves and stems of E. variegata L. for research and development of anti-obese agent.

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Jun 30, 2023
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Nguyen, P.-H., S. Xayavong, N.-T.-V. Trinh, D. N. Quang, L. T. P. Hoa, T.-T. Do, T.-H. Vu, T.-T. Bui, và T.-T.-H. Trinh. “α-Glucosidase Inhibitors from the Leaves and Stems of Erythrina Variegata L. Collected in Hanoi”. Tạp Chí Khoa học Và Công nghệ - Đại học Đà Nẵng, vol 21, số p.h 6.1, Tháng Sáu 2023, tr 71-74, doi:10.31130/ud-jst.2023.040E.

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