The cytotoxic activity of lignans and monoterpenoids from the male carica papaya flowers on A549 lung cancer, Hep3B liver cancer, and MCF-7 breast cancer cell lines

https://doi.org/10.31130/ud-jst.2023.523E
Tóm tắt: 67 | PDF: 83

##plugins.themes.academic_pro.article.main##

Author

  • Do Thi Thuy Van
    The University of Danang - University of Science and Education, Danang, Vietnam

Từ khóa:

A549 lung cancer cells
Hep3B liver cancer cells
lignan
MCF-7 breast cancer cells
monoterpenoid

Tóm tắt

Two lignans (lariciresinol (1) and dehydrodiconiferyl alcohol (2)), and four monoterpenoids (vitexoid (3), 6-hydroxy-2,6-dimethyl-2,7-octadienoic acid (4), 6-hydroxy-2,6-dimethyloct-7-enoic acid (5), 2,6-dimethylocta-2,7-diene-1,6-diol (6)) from the male Carica papaya flowers are conducted a cytotoxic activity for lung cancer cells (A549), liver cancer cells (Hep3B), and breast cancer cells (MCF-7). The results, lignan (1), and monoterpenoid (3), (6) exhibited medium cytotoxic activity on these cancer cells with IC50 from 34.73±1.55 to 66.12±5.60 µg/mL. Lignan (2) displayed medium cytotoxic activity on MCF-7, Hep3B with IC50 60.85±4.43, 62.32±
5.03 µg/mL, respectively, and weak cytotoxic activity on A549 with IC50 70.99±7.26 µg/mL. Monoterpenoids (4), and (5) showed medium cytotoxic activity on MCF-7 with IC50 54.15±5.89, 67.49±2.41 µg/mL, respectively, and weak cytotoxic activity on A549, and Hep3B with IC50 from 72.25±3.13 to 86.03±7.57 µg/mL. Ellipticine was a positive control.

Tài liệu tham khảo

    [1] H. K. Ikram, R. Stanley, M. Netzel, and K. Fanning, "Phytochemicals of papaya and its traditional health and culinary uses - a review", J. Food. Composit. Anal., vol. 41, pp. 201-211, 2015. https://doi.org/10.1016/j.jfca.2015.02.010.
    [2] M. Wall, "Ascorbic acid, vitamin A, and mineral composition of banana (Musa sp.) and papaya (Carica papaya) cultivars grown in Hawaii", J. Food. Composit. Anal., vol. 19, no. 5, pp. 434-445, 2006. https://doi.org/10.1016/j.jfca.2006.01.002.
    [3] Rahman et al., "Antibacetial screening of leaves and stem of Carica papaya", J. Med. Plant. Res., vol. 5, no. 20, pp. 5167-5171, 2011.
    [4] T. T. Thao, P. N. Shaw, M. O. Parat, and A. K. Hewavitharana, "Cytotoxic activity of Carica papaya: A review", Mol. Nut. Food. Res., vol. 57, no. 1, pp. 153-164, 2013. https://doi.org/10.1002/mnfr.201200388.
    [5] T. Ha, D. T. H. Vien, and L. Q. Hoa, "The study on bioactive properties of some compounds from Carica papaya leaves", Vietnam J. Sci. Tech., vol. 2, no. 3, pp. 119-120, 2014.
    [6] T. T. Van, D. H. Cuong, G. T. K. Lien, and N. T. Q. Mai, "Cytotoxicity activity and chemical compositions of male Carica papaya leaves in Quangnam - Danang", Vietnam J. Pharm., vol. 510, no. 58, pp. 78-81, 2018.
    [7] T. K. Lien, D. T. T. Van, D. H. Cuong, P. H. Yen, B. H. Tai, and P. V. Kiem, "A new phenolic constituent from Carica papaya flowers and its tyrosinase inhibitory activity", J. Nat. Prod. Commu., vol. 14, no. 7, pp. 1-3, 2019. https://doi.org/10.1177/1934578X19850987.
    [8] T. T. Van, D. H. Cuong, G. T. K. Lien, and P. H. Yen, "Phytochemical study of the ethyl acetate extract of male Carica papaya flowers from Quangnam - Danang", Vietnam J. Chem., vol. 58, no. 2, pp. 145-150, 2020. https://doi.org/10.1002/vjch.201900029.
    [9] Nainggolan and Kasmira, "Cytotoxicity activity of male Carica papaya flowers on MCF-7 breast cancer cells", J. Chem. Pharm. Res., vol. 7, no. 5, pp. 772-775, 2015.
    [10] T. T. Van and G. T. K. Lien, "Screening test on cytotoxic activity of some extract from the male papaya flower from Quangnam - Danang", The University of Danang - J. Sci.Tech., vol. 11, no. 120, pp. 100-103, 2017.
    [11] P. Sianipar, E. Suwarso, and R. Rosidah, "Antioxidant and cytotoxic activity of hexane fraction from Carica papaya L. male flower", Asian J. Pharma. Clinic. Res., vol. 11, no. 3, pp. 81-83, 2018. https://doi.org/10.22159/ajpcr.2018.v11i3.22382.
    [12] T. Nga, N. T. H. Trang, N. T. A. Tuyet, N. K. P. Phung, N. T. T. Dương, and N. T. H. Thu, "Ethanol extract of male Carica papaya flowers demonstrated non-toxic against MCF-7, Hep-G2, Hela, NCI-H460 cancer cell lines", Vietnam J. Chem., vol. 58, no. 1, pp. 86-90, 2020. https://doi.org/10.1002/vjch.2019000142.
    [13] Monks et al., "Feasibility of a high-flux cytotoxic drug screen using a diverse panel of cultured human tumor cell lines", J. National Cancer Inst., vol. 83, no. 11, pp. 757-766, 1991. https://doi.org/10.1093/jnci/83.11.757.
    [14] Masuda, J. Akiyama, A. Fujimoto, S. Yamauchi, T. Maekawa, and Y. Sone, "Antioxidation reaction mechanism studies of phenolic lignans, identifications of antioxidation products of secoisolariciresinol from lipid oxidation", Food. Chem., vol. 132, no. 2, pp. 442-450, 2010. https://doi.org/10.1016/j.foodchem.2010.04.065.
    [15] S. M. Yuen, F. Xue, T. C. W. Mak, and H. N. C. Wong, "On the absolute structure of optically active neolignans containing a dihydrobenzo[b] furan skeleton", Tetrahedron, vol. 54, no. 41, pp. 12429-12444, 1998. https://doi.org/10.1016/S0040-4020(98)00725-X.
    [16] Wu, T. Zhou, S. W. Zhang, X. H. Zhang, and L. J. Xuan, "Cytotoxic terpenoids from the fruits of Vitex trifolia L.", Planta. Med., vol. 75, no. 4, pp. 367-370, 2009. https://doi.org/10.1055/s-0028-1112211.
    [17] L. Arslanian, T. Anderson, and F. R. Stermitz, "Iridoid glucosides of Penstemon ambiguus", J. Nat. Prod., vol. 53, no. 6, pp. 1485-1489, 1990. https://doi.org/10.1021/np50072a013.
    [18] A. S. Pope, G. E. Burtin, P. T. Clayton, D. J. Madge, and D. P. R. Muller, "New synthesis of (±)-alpha-CMBHC and its confirmation as a metabolite of alpha-tocopherol (vitamin E)", Bioorg. Med. Chem., vol. 9, no. 5, pp. 1337-1343, 2001. https://doi.org/10.1016/S0968-0896(01)00010-4.
    [19] Skold, A. Borje, E. Harambasic, and A. T. Karlberg, "Contact allergens formed on air exposure of linalool. Identification and quantification of primary and secondary oxidation products and the effect on skin sensitization", Chem. Res. Toxicol., vol. 17, no. 12, pp. 1697-1705, 2004. https://doi.org/10.1021/tx049831z.
    [20] G. Calvo-Flores, J. A. Dobado, J. Isac-Garcia, and F. J. Martin-Martinez, Lignin and Lignans as Renewable Raw Materials: Chemistry, Technology and Applications. United Kingdom: John Wiley & Sons Ltd, 2015.
    [21] P. Xu, Cancer Inhibitors from Chinese Natural Medicines. Taylor & Francis Group: CRC Press, 2017.
    [22] J. Ma et al., "Proteomic analysis of apoptosis induction by lariciresinol in human HepG2 cells", Chem. Bio. Inter., vol. 256, pp. 209-219, 2016. https://doi.org/10.1016/j.cbi.2016.07.011.
    [23] Lee et al., "Dehydrodiconiferyl Alcohol Isolated from Cucurbita moschata Shows Anti-adipogenic and Anti-lipogenic Effects in 3T3-L1 Cells and Primary Mouse Embryonic Fibroblasts", J. Bio. Chem., vol. 287, no. 12, pp. 8839-8851, 2012. https://doi.org/10.1074/jbc.M111.263434.
    [24] Lee, K. R. Ko, H. K. Kim, S. Lim, and S. Kim, "Dehydrodiconiferyl Alcohol Promotes BMP-2-induced Osteoblastogenesis Through its Agonistic Effects on Estrogen Receptor", Biochem. Biophys. Res. Commu., vol. 459, no. 3, pp. 2242-2248, 2018. https://doi.org/10.1016/j.bbrc.2017.12.079.
    [25] N. F. Salakhutdinov, K. P. Volcho, and O. I. Yarovaya, "Monoterpenes as a renewable source of biologically active compounds", Pure Appl. Chem., vol. 89, no. 8, pp. 1105-1117, 2017. https://doi.org/10.1515/pac-2017-0109.
Xem thêm

##plugins.themes.academic_pro.article.sidebar##

Đã Xuất bản

Dec 31, 2023
Download
PDF (English)
Cách trích dẫn
Van, D. T. T. “The Cytotoxic Activity of Lignans and Monoterpenoids from the Male Carica Papaya Flowers on A549 Lung Cancer, Hep3B Liver Cancer, and MCF-7 Breast Cancer Cell Lines”. Tạp Chí Khoa học Và Công nghệ - Đại học Đà Nẵng, vol 21, số p.h 12.1, Tháng Chạp 2023, tr 117-21, doi:10.31130/ud-jst.2023.523E.

##plugins.themes.academic_pro.article.details##