Tổng hợp hạt lai nhạy nhiệt từ poly(N-isopropylacrylamide) và silica
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Từ khóa:
N-isopropylacrylamide
silica
hạt lai nhạy nhiệt
cấu trúc vỏ-lõi
Tóm tắt
Nghiên cứu đã tổng hợp thành công hạt lai kết hợp giữa lõi poly(N-isopropylacrylamide) (PNIPAM) và vỏ silica dựa trên hai cách tiếp cận. Với cách tiếp cận thứ nhất, N,N′-methylenebisacrylamide (MBA) được dùng làm tác nhân liên kết ngang trong quá trình hình thành lõi hạt P(NIPAM/AM), tiếp theo là quá trình lắng đọng của tiền chất silica trên bề mặt lõi thông qua phản ứng sol-gel với sự hiện diện của 3-glycidyloxypropyltrimethoxysilane (GLYMO). Hạt lai P(NIPAM/AM/ MBA)@silica thu được có dạng hình cầu, cấu trúc vỏ-lõi, phân bố kích thước hẹp, và vẫn giữ được đặc tính nhạy nhiệt. Tuy nhiên, đường kính hạt tương đối to (563,5±28,2 nm). Theo cách thứ hai (không dùng MBA), các hạt lai P(NIPAM/AM)@silica được tổng hợp từ các chuỗi P(NIPAM/AM) trong trạng thái co ở 50°C làm chất tạo mầm cho quá trình bọc silica trong sự hiện diện của GLYMO. Kết quả thu được hạt lai P(NIPAM/AM)@silica có hình dạng, cấu trúc và tính chất tương tự P(NIPAM/AM/MBA)@silica nhưng đường kính chỉ 68,7±6,2 nm. Kết quả thu được đã mở ra tiềm năng ứng dụng của vật liệu lai giữa PNIPAM và silica trong lĩnh vực dẫn truyền thuốc.
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Nov 30, 2020
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Cao Luu Ngoc Hanh, Nguyen Thi Bich Thuyen, Luong Huynh Vu Thanh, Doan Van Hong Thien, Ngo Truong Ngoc Mai. “Tổng hợp hạt Lai nhạy nhiệt từ poly(N-Isopropylacrylamide) Và Silica”. Tạp Chí Khoa học Và Công nghệ - Đại học Đà Nẵng, vol 18, số p.h 11, Tháng Mười-Một 2020, tr 33-38, https://jst-ud.vn/jst-ud/article/view/3522.
