Cấu trúc và hoạt tính chống oxy hoá của một số hợp chất flavonoid phân lập từ lá cây mơ lông (Paederia lanuginosa) thu hái tại Quảng Nam, Việt Nam
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Nguyễn Quang TrungTrường Đại học Sư phạm - Đại học Đà Nẵng; Trung tâm Kỹ thuật Tiêu chuẩn Đo lường Chất lượng 2, Việt NamĐào Hùng CườngTrường Đại học Sư phạm - Đại học Đà Nẵng, Đà Nẵng, Việt NamVõ Văn QuânTrường Đại học Sư phạm Kỹ thuật - Đại học Đà Nẵng, Đà Nẵng, Việt Nam
Từ khóa:
Flavonoid
Paederia Lanuginose
hoạt tính chống oxy hoá
hằng số tốc độ phản ứng
bước chuyển đơn điện tử
Tóm tắt
Từ dịch chiết EtOAC của lá cây Mơ lông (Paederia Lanuginose) đã phân lập được ba hợp chất flavonoid, gồm kaempferol (KF), quercetin (QCT) và quercitrin (QCTR). Cấu trúc của các hợp chất này được xác định bằng các dữ liệu phổ NMR kết hợp với tài liệu tham khảo. Hoạt tính chống oxy hoá của các hợp chất trong môi trường nước (pH 7,4) cũng đã được đánh giá thông qua phương pháp tính toán hoá học. Kết quả cho thấy, cả ba hợp chất được phân lập thể hiện hoạt tính chống oxy hoá tốt với hằng số tốc độ phản ứng bắt gốc tự do tổng quát lần lượt là 6,2×106, 8,0×106 và 1,4×106. Trạng thái dianion của các hợp chất trong môi trường nước (pH 7,4) là thành phần chính đóng góp vào khả năng bắt gốc tự do của các hợp chất này, trong khi đó vai trò của trạng thái anion là không đáng kể. Bên cạnh đó, nhóm thế hydroxyl tại vị trí O‒3ʹ cũng như liên kết glycosidic tại vị trí O‒3 của hợp chất KF không ảnh hưởng đến hoạt tính chống oxy hoá của các hợp chất nghiên cứu.
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Nguyen Quang Trung, Dao Hung Cuong, và Quan V. Vo. “Cấu Trúc Và hoạt tính chống Oxy Hoá của một số hợp chất Flavonoid phân lập từ Lá cây Mơ lông (Paederia Lanuginosa) Thu hái tại Quảng Nam, Việt Nam”. Tạp Chí Khoa học Và Công nghệ - Đại học Đà Nẵng, vol 21, số p.h 8.2, Tháng Tám 2023, tr 124-35, https://jst-ud.vn/jst-ud/article/view/8495.
