Research on the extraction, phytochemistry and biological activity of the methanol extract from Mirabilis jalapa L. flowers

Tóm tắt

The concentrated methanolic extract of Mirabilis jalapa L. flowers was prepared using ultrasound-assisted extraction at a ratio of flower power (g)/methanol (mL) of 1/25, for 40 minutes with 3 ultrasonic cycles. Phytochemical screening indicated the presence of saponins, alkaloids, coumarins, flavonoids, polyphenols, steroids, and carboxylic acids. GC-MS analysis of the volatile constituents of the methanol extract identified 16 compounds, with carboxylic acids and their derivatives constituting the major components. Simultaneously, the extract exhibited DPPH antioxidant activity (IC₅₀ of 41.47±2.28 µg/mL), inhibited HepG2 cells with a percentage of 29.58±1.54% at a concentration of 100 µg/mL, and α-glucosidase enzyme with a percentage of 30.56±1.37% at a concentration of 500 µg/mL.