Chemical composition and cytotoxic activity of the methanol extract from Polycarpaea corymbosa (L.) Lam roots
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Polycarpaea corymbosa (L.) Lam
root
methanolic extract
HepG2
MCF-7
Tóm tắt
Polycarpaea corymbosa (L.) Lam, a traditional medicinal plant known for its cooling and diuretic properties, is commonly used in folk medicine for both internal and topical applications. The methanol root extract of Polycarpaea corymbosa (L.) Lam was prepared using ultrasound-assisted extraction. Phytochemical screening indicated the presence of alkaloids, coumarins, flavonoids, polyphenols, reducing sugars, carboxylic acids, and steroids. GC-MS analysis of the volatile constituents of the methanol extract identified 17 compounds, with carboxylic acids and their derivatives constituting the major components. Furthermore, the extract exhibited notable cytotoxicity against HepG2 and MCF-7 cell lines, with IC50 values (µg/mL) of 14.81 ± 0.77 and 25.89 ± 2.02, respectively. The results suggest that the methanolic root extract of Polycarpaea corymbosa (L.) Lam shows potential as an adjunct anticancer agent against HepG2 and MCF-7 cell lines.
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Jun 30, 2026
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Van, D. T. T., và T. Q. Dan. “Chemical Composition and Cytotoxic Activity of the Methanol Extract from Polycarpaea Corymbosa (L.) Lam Roots”. Tạp Chí Khoa học Và Công nghệ Đại học Đà Nẵng, vol 24, số p.h 6A, Tháng Sáu 2026, tr 96-100, doi:10.31130/ud-jst.2026.24(6A).160E.
