Tổng hợp và xác định cấu trúc của một số dẫn xuất 1,5-disubstituted-4-ethoxycarbonyl-3-hydroxy-3-pyrroline-2-one chứa nhóm nitro
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Từ khóa:
Multi-component reaction
γ-lactam ring;
2-pyrrolidinone
3-pyrroline-2-one
1,5-dihydro-2H-pyrrol-2-one
Tóm tắt
2-Pyrrolidinone là một dị vòng γ-lactam chứa bốn nguyên tử carbon và một nguyên tử nitrogen. Trong nhóm các dẫn xuất 2-pyrrolidinone, 1,5-dihydro-2H-pyrrol-2-one, còn được gọi là các dẫn xuất 3-pyrroline-2-one là những đơn vị cấu trúc quan trọng trong nhiều hợp chất thiên nhiên có hoạt tính sinh học. Hơn nữa, dị vòng γ-lactam này còn có mặt trong cấu trúc của một số loại dược phẩm. Trong nghiên cứu này, ba dẫn xuất của 4-ethoxycarbonyl-3-hydroxy-3-pyrroline-2-one chứa nhóm nitro (–NO2) đã được tổng hợp dựa vào phản ứng nhiều thành phần (MCR) từ aldehyde thơm, 4-nitroaniline và sodium diethyl oxalacetate trong dung môi ethanol. Ngoài ra, cấu trúc của các sản phẩm đã được chứng minh dựa vào các phương pháp phổ hiện đại như phổ cộng hưởng từ hạt nhân (1H NMR, 13C NMR) và phổ khối phân giải cao (ESI – HRMS)
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Cách trích dẫn
Nguyen, N. T., và V. V. Dai. “Tổng hợp Và xác định cấu Trúc của một số dẫn xuất 1,5-Disubstituted-4-Ethoxycarbonyl-3-Hydroxy-3-Pyrroline-2-One chứa nhóm Nitro”. Tạp Chí Khoa học Và Công nghệ - Đại học Đà Nẵng, vol 22, số p.h 3, Tháng Ba 2024, tr 72-77, doi:10.31130/ud-jst.2024.568E.
