Nghiên cứu quá trình tautomer hoá enol – enol của 5-(4-chlorophenyl)-1-phenyl-4-acetyl-3-hydroxy -3- pyrrolin-2-one dựa vào phổ cộng hưởng từ hạt nhân được đo trong dung môi DMSO-d6
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Từ khóa:
Tautomerism
tautomerization
enol – enol tautomerism
1,5-disubstituted-4-acetyl-3-hydroxy-3-pyrrolin-2-one
enol – enol tautomerization
Tóm tắt
Tautomer hoá là một hiện tượng hoá học đặc biệt liên quan đến sự chuyển dịch của một nguyên tử hydrogen giữa các dạng tautomer khác nhau. Ngoài ra, quá trình cân bằng động học này cũng đóng vai trò rất quan trọng trong nghiên cứu hoá dược hiện đại do sự có mặt của nó trong cơ chế hoạt động của nhiều loại thuốc. Trong nghiên cứu này, quá trình tautomer hoá enol – enol của hợp chất 5-(4-chlorophenyl)-1-phenyl-4-acetyl-3-hydroxy-3-pyrrolin-2-one trong dung môi dimethyl sulfoxide đã được nghiên cứu dựa vào phổ cộng hưởng từ hạt nhân. Kết quả ghi phổ đã cho thấy cân bằng hoá học giữa hai cấu trúc tautomer dạng enol đã xảy ra nhanh hơn so với khả năng ghi nhận các tần số cộng hưởng riêng lẻ ở mỗi tautomer của thiết bị đo và dẫn đến xuất hiện một số peak chân rộng trong phổ 13C NMR. Đặc biệt, tương tác spin – spin giữa các nguyên tử hydrogen và carbon trong hợp chất đã được ghi nhận và phân tích thông qua các phổ hai chiều HSQC và HMBC.
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Nguyen, N. T. “Nghiên cứu Quá trình Tautomer Hoá Enol – Enol của 5-(4-Chlorophenyl)-1-Phenyl-4-Acetyl-3-Hydroxy -3- Pyrrolin-2-One dựa vào phổ cộng hưởng từ hạt nhân được đo Trong Dung môi DMSO-D6”. Tạp Chí Khoa học Và Công nghệ - Đại học Đà Nẵng, vol 23, số p.h 5A, Tháng Năm 2025, tr 106-10, doi:10.31130/ud-jst.2025.147E.
