Synthesis and structural determination of pyrrolidine-2,3-dione derivatives from 4-acetyl-3-hydroxy-5-phenyl-1-(3-nitrophenyl)-3-pyrroline-2-one

https://doi.org/10.31130/ud-jst.2023.519E

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Author

  • Nguyen Tran Nguyen
    The University of Danang - University of Science and Education, Danang, Vietnam
    Vo Viet Dai
    The University of Danang - University of Science and Education, Danang, Vietnam

Từ khóa:

2-pyrrolidinone
3-pyrrolin-2-one
1,4,5-trisubstituted pyrrolidine-2,3-dione
1,5-dihydro-2H-pyrrol-2-one
multi-component reaction

Tóm tắt

Numerous heterocyclic compounds containing
3-pyrroline-2-one or pyrrolidine-2,3-dione core have been found in nature and showed valuable biological activities. Therefore, the synthesis of 3-pyrroline-2-one derivatives and pyrrolidine-2,3-dione derivatives have attracted more and more attention from organic chemists and medicinal chemists. In this manuscript, 4-acetyl-3-hydroxy-1-(3-nitrophenyl)-5-phenyl-3-pyrroline-2-one has been prepared via three-component reaction and, besides, two 1,4,5-trisubstituted pyrrolidine-2,3-diones have also been synthesized via the reaction between the above 3-pyrroline-2-one derivative and aliphatic amine such as methylamine and 4-methoxybenzylamine. The structure of desired products have been confirmed via 1D NMR (1H NMR, 13C NMR), 2D NMR (HSQC, HMBC) and high resolution mass spectrometry (ESI – HRMS).

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Jun 30, 2023
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Cách trích dẫn
Nguyen, N. T., và V. V. Dai. “Synthesis and Structural Determination of Pyrrolidine-2,3-Dione Derivatives from 4-Acetyl-3-Hydroxy-5-Phenyl-1-(3-Nitrophenyl)-3-Pyrroline-2-One”. Tạp Chí Khoa học Và Công nghệ - Đại học Đà Nẵng, vol 21, số p.h 6.1, Tháng Sáu 2023, tr 61-66, doi:10.31130/ud-jst.2023.519E.

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