Ethyl 1-benzyl-2-(4-methylphenyl)-1h-pyrrolo[2,3-b]quinoxaline- 3-carboxylate và ethyl 6,7-dimethyl-1,2- diphenyl-1h-pyrrolo[2,3-b]quinoxaline-3-carboxylate: tổng hợp và phân tích phổ cộng hưởng từ hạt nhân

https://doi.org/10.31130/ud-jst.2025.094E

Tóm tắt: 155 | PDF: 146

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Author

  • Vo Viet Dai
    The University of Danang - University of Science and Education, Vietnam
    Bui Bich Loc
    The University of Danang - University of Science and Education, Vietnam
    Nguyen Tran Nguyen
    The University of Danang - University of Science and Education, Vietnam

Từ khóa:

1,5-disubstituted-3-hydroxy-3-pyrroline-2-ones
pyrrolo[2,3-b]quinoxalines
quinoxaline derivatives
multi-component reaction
γ-lactam ring

Tóm tắt

Nhiều dẫn xuất pyrrolo[2,3-b]quinoxaline đã được tổng hợp và qua khảo sát cho thấy chúng có hoạt tính sinh học, dược động học có giá trị. Tuy nhiên, các phương pháp sử dụng xúc tác kim loại nặng trong quá trình tổng hợp đã làm hạn chế việc ứng dụng các phương pháp này trong công nghiệp hoá dược. Trong nghiên cứu này, hai dẫn xuất pyrrolo[2,3-b]quinoxaline đã được tổng hợp thông qua phản ứng cộng nucleophile giữa hai dẫn xuất 1,5-disubstituted-4-ethoxycarbonyl-3-hydroxy-3-pyrroline-2-one và tác nhân nucleophile là o-phenylenediamine hoặc 4,5-dimethyl-o-phenylenediamine trong dung môi acetic acid khan. Trong môi trường acid của acetic acid, các hợp chất 1,5-disubstituted-4-ethoxycarbonyl-3-hydroxy-3-pyrroline-2-one có thể bị tautomer hoá thành dạng keto, còn được gọi là các dẫn xuất 2,3-dioxopyrrolidine. Ngoài ra, cấu trúc của hai dẫn xuất pyrrolo[2,3-b]quinoxaline cũng đã được phân tích và chứng minh dựa vào phổ cộng hưởng từ hạt nhân và phổ khối phân giải cao.

Tài liệu tham khảo

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May 31, 2025
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Dai, V. V., B. B. Loc, và N. T. Nguyen. “Ethyl 1-Benzyl-2-(4-Methylphenyl)-1h-pyrrolo[2,3-b]quinoxaline- 3-Carboxylate Và Ethyl 6,7-Dimethyl-1,2- Diphenyl-1h-pyrrolo[2,3-b]quinoxaline-3-Carboxylate: Tổng hợp Và phân tích phổ cộng hưởng từ hạt nhân”. Tạp Chí Khoa học Và Công nghệ - Đại học Đà Nẵng, vol 23, số p.h 5A, Tháng Năm 2025, tr 90-96, doi:10.31130/ud-jst.2025.094E.

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